Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease뒤집힌 U: SARS-CoV-2 엔도리보뉴클레아제에 의한 dsRNA 절단의 구조적 기초Article Published on 2022-08-122022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, 치료법, [키워드] activate Activation active site cleavage cleave coronavirus coronavirus Coronavirus replication Critical cryo-EM structure cryo-EM structures double-stranded dsRNA endoribonuclease evade form generate Host immune MDA5 mechanism Nsp15 Pattern recognition pattern recognition receptor platform processing recognize replication-transcription complex RNA SARS-CoV-2 SARS-CoV-2 Nsp15 single-stranded site-directed mutagenesis structures substrates the SARS-CoV-2 uridine Vesicle viral replication [DOI] 10.1093/nar/gkac589 PMC 바로가기 [Article Type] Article
Structural diversity of the SARS-CoV-2 Omicron spikeSARS-CoV-2 오미크론 스파이크의 구조적 다양성Article Published on 2022-06-022022-09-11 Journal: Molecular Cell [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Analysis changes in communication conformational conformational change Critical cryo Cryo-electron microscopy cryo-EM structure cryo-EM structures Crystallography Delta delta variant determine domain dominant electron microscopy epitope fusion peptide immune immune evasion Impact interprotomer communication intraprotomer communication Mutation Neutralizing Neutralizing antibodies neutralizing antibody omicron Omicron spike peptide RBD Receptor-binding domain SARS-CoV-2 evolution spike Spike protein the SARS-CoV-2 Transmissibility variant vector analysis. virus transmissibility X-ray X-ray crystallography [DOI] 10.1016/j.molcel.2022.03.028 PMC 바로가기 [Article Type] Article
Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Spike. Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article
Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617B.1.617에 대한 효능을 유지하는 단일특이성 및 이중특이성 단일클론 SARS-CoV-2 중화 항체Article Published on 2022-03-282022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] analysis antibody B cell B cells B.1.617 B.1.617.2 binding patterns Breakthrough infection breakthrough infections caused clone complex conformations COVID-19 Critical cryo-EM structure cryo-EM structures death delta variant ectodomain Efficacy Epitopes expand facilitate functional generate humanized identify immunized in vivo inhibitory activity lead mAb mAbs maintain monoclonal monoclonal antibodies monoclonal antibody nanomolar affinity neutralize Neutralizing Neutralizing antibodies neutralizing antibody occur pathogen prefusion Prophylactic RBD Receptor binding domain repertoire SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants single cell sequencing Spike receptor binding domain spike trimer therapeutic therapeutic option Therapeutics translation Vaccine variants variants of concern virus [DOI] 10.1038/s41467-022-29288-3 PMC 바로가기 [Article Type] Article
Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodiesACE2 수용체 및 광범위 중화 항체의 SARS-CoV-2 Delta 변이체 인식을 위한 구조적 기반Article Published on 2022-02-152022-09-10 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor affinity Antibody neutralization antigenic binding circulating complex conformational conformational state contribute cryo-EM Cryo-EM analysis cryo-EM structure cryo-EM structures Cryoelectron microscopy Delta delta variant destabilized dominant effective Engagement FIVE identify immune induce Interaction lead mAbs mechanism Mutation Neutralizing neutralizing antibody pathogenicity RBD RBM receptor SARS-CoV-2 sensitivity shedding Spread T478K tested Transmission Viral proteins [DOI] 10.1038/s41467-022-28528-w PMC 바로가기 [Article Type] Article
Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EMArticle Published on 2021-12-202022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor Analysis association Beta biochemical Combination Combined complex complexes Complexes conformational conformational state COVID-19 pandemic cryo-EM cryo-EM structure cryo-EM structures Cryoelectron microscopy distribution domain immune evasion IMPROVE mechanism modify Mutation Neutralizing neutralizing antibody pathogenicity Protein RBD Receptor binding recognize S protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spikes Structure the S protein Transmissibility understanding variant variant spike variants virus wild-type [DOI] 10.1038/s41467-021-27350-0 PMC 바로가기 [Article Type] Article
A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants비 ACE2 경쟁 인간 단일 도메인 항체는 SARS-CoV-2 및 순환 변이체에 대한 광범위한 중화를 제공합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 affinity Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody B.1.1.7 B.1.351 B.1.617.2 Beta bind binding circulating variant clinical development competing complex conformation COVID-19 COVID-19 pandemic cryo-EM structure cryo-EM structures crystal structure Delta effective epitope exhibit Gamma global public health host cell host cell receptor humanized Immune escape Infectious diseases inhibit lineages membrane fusion mice Mutation neutralization Neutralizing P.1 prevalent Prophylactic Pseudovirus neutralization assay RBD Receptor-binding domain reveal SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S SARS-CoV-2 variants structural biology the receptor-binding domain therapeutic therapeutic antibodies treat Vaccine variant [DOI] 10.1038/s41392-021-00810-1 PMC 바로가기 [Article Type] Article
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses짝을 이루는 중쇄 및 경쇄 서명은 공개 항체 반응에서 강력한 SARS-CoV-2 중화에 기여합니다Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 analysis antibody Antibody Response B cells B-cell binding interaction binding interactions Biotechnology contribute convalescent COVID-19 patients cryo cryo-EM structures determine develop feature functional Genes Genetic highlight immune Immunity mechanism medical intervention member monoclonal antibody neutralization precursor Prevalence Protective Protective antibody public antibody SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 spike trimer sequence sequence similarity spike trimer Structure the SARS-CoV-2 Therapeutic strategies therapeutic strategy understanding Vaccine Virology yeast yeast display. [DOI] 10.1016/j.celrep.2021.109771 PMC 바로가기 [Article Type] Article
A method for intuitively extracting macromolecular dynamics from structural disorderArticle Published on 2021-09-172022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] accounted Analysis approach conformations Cryo-electron microscopy cryo-EM structures disorder example Factors Hierarchical hypothese Implications information macromolecular molecular molecular mechanisms parameter Proteins Quantitative SARS-CoV-2 SARS-CoV-2 proteins STEAP4 Structural analysis structural biology Structure Structure determination structures temperature [DOI] 10.1038/s41467-021-25814-x PMC 바로가기 [Article Type] Article
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopesArticle Published on 2021-08-032022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] ACE2-binding site acute respiratory syndrome Analysis antibodies Antiviral bind binding binding epitope circulating variant circulating variants class comparison conserved coronavirus COVID-19 therapeutics cryo-EM structures Cryoelectron microscopy determine disrupt effective eight epitope host receptor inaccessible indicate mechanisms Microbiology Microscopy nanobody neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody neutralizing epitope potent provided RBD Receptor binding domain recognize reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Spike protein STABLE structural biology Structure target the SARS-CoV-2 unique Vaccine variant variants of concern variety virus VoC VOCs [DOI] 10.1038/s41467-021-24963-3 PMC 바로가기 [Article Type] Article